Description

2'-o-Monobutyryladenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt CAS NO 152218-23-0 is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical and pharmacological research. This compound is critical for studying cAMP-dependent signaling pathways with enhanced stability and specificity, as the Rp-isomer acts as a competitive inhibitor of cAMP-dependent protein kinase (PKA). It is an essential tool for researchers and developers in pharmaceutical discovery, molecular biology, and signal transduction studies, where precise modulation of intracellular cAMP levels is required.

Application

• Biochemical Research: As a potent and selective inhibitor of Protein Kinase A (PKA) for investigating cAMP-mediated signal transduction pathways.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify novel therapeutics targeting heart failure, asthma, and other cAMP-related disorders.
• Cell Biology Studies: Tool for probing the role of cAMP in cellular processes such as metabolism, gene expression, and ion channel regulation.
• Neuroscience Research: Investigation of synaptic plasticity, memory formation, and neurotransmitter release mechanisms influenced by PKA activity.
• Diagnostic Reagent Manufacturing: A key component in the development of ELISA kits and other diagnostic assays for cAMP pathway analysis.
• Academic Research: Fundamental studies in universities and research institutes on second messenger systems and enzyme kinetics.

Basic Information

Product Name	2'-o-Monobutyryladenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	152218-23-0
Molecular Formula	C18H22N5O10P S . xNa
Molecular Weight	Approx. 577.4 g/mol (free acid)
Synonyms	Rp-cAMPS 2'-O-Butyryl; Rp-2'-O-Monobutyryladenosine-3',5'-cyclic monophosphorothioate sodium salt; Rp-2'-O-Bu-cAMPS; cAMP analog Rp-isomer; Adenosine 2'-O-butyryl-3',5'-cyclic monophosphorothioate, Rp-isomer, sodium salt; Protein Kinase A Inhibitor (Rp-isomer); Rp-2'-O-Butyryl-cAMPS sodium salt; 2'-O-Butyryl-Rp-adenosine-3',5'-cyclic monophosphorothioate sodium salt
EINECS	Contact for details

Quality Control

Our 2'-o-Monobutyryladenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.