Description

1-(2',3'-Epithio-2',3'-Dideoxy-β-D-Ribofuranosyl)Thymine 5'-Triphosphate is a chemically modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and development. Its unique epithio-dideoxyribose structure makes it a valuable tool for probing enzyme mechanisms and developing novel therapeutic agents. This high-purity compound is essential for researchers and developers in pharmaceutical discovery, molecular biology, and enzymology who require precise and reliable synthetic intermediates.

Application

• Enzyme Inhibition Studies: Used as a substrate analog to investigate the active sites and catalytic mechanisms of DNA polymerases, reverse transcriptases, and other nucleotide-processing enzymes.
• Antiviral Drug Development: Serves as a key precursor or active metabolite in the research of nucleoside reverse transcriptase inhibitors (NRTIs) for targeting viral replication.
• Mechanistic Biochemistry: Employed in kinetic and structural studies to understand the fidelity and selectivity of nucleic acid synthesis.
• Probe Synthesis: Utilized for the chemical synthesis of labeled or modified oligonucleotides for diagnostic assays and biophysical studies.
• Medicinal Chemistry Research: Acts as a sophisticated intermediate in the synthesis of novel nucleoside analogs with potential therapeutic applications.

Basic Information

Product Name	1-(2',3'-Epithio-2',3'-Dideoxy-β-D-Ribofuranosyl)Thymine 5'-Triphosphate
CAS No.	152158-10-6
Molecular Formula	C15H22N3O13P3S
Molecular Weight	577.31 g/mol
Synonyms	2',3'-Epithio-2',3'-dideoxy-TTP; 1-[(2S,3R,4R,5R)-5-(Hydroxyphosphinatooxyphosphoryl)oxymethyl-3,4-bis(oxidanyl)-2-sulfanylidene-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione; d4TTP Episulfide Analog; Thymidine 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy-2',3'-epithio-; 2',3'-Epithio-2',3'-dideoxythymidine 5'-triphosphate; Modified Nucleotide Triphosphate; Episulfide-d4TTP
EINECS	Contact for details

Quality Control

Our 1-(2',3'-Epithio-2',3'-Dideoxy-β-D-Ribofuranosyl)Thymine 5'-Triphosphate is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive research applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.