Description

4-Bromo-2-Fluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce both bromo and fluoro substituents onto a benzoyl scaffold, enabling precise molecular modifications for performance-driven applications. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs for enhanced bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromo and fluoro groups can significantly influence binding affinity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for creating advanced organic electronic materials, where halogenated aromatic units are crucial for tuning electronic properties and molecular alignment.
• Polymer Chemistry: Employed in the production of specialty polymers and high-performance resins, where it can function as a monomer or cross-linking agent.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.
• Peptide & Protein Modification: Can be used to acylate amino groups or modify specific residues in peptides and biomolecules for biochemical studies.

Basic Information

Product Name	4-Bromo-2-Fluorobenzoyl Chloride
CAS No.	151982-51-3
Molecular Formula	C7H3BrClFO
Molecular Weight	237.45 g/mol
Synonyms	2-Fluoro-4-bromobenzoyl chloride; 4-Bromo-2-fluorobenzoic acid chloride; Benzoic acid, 4-bromo-2-fluoro-, chloride; 4-Bromo-2-fluorobenzoylchloride; 2-Fluoro-4-bromobenzoic acid chloride; 4-Bromo-2-fluorobenzenecarbonyl chloride; p-Bromo-o-fluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorobenzoyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to verify identity and purity against stringent internal specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We are committed to meeting the quality standards required for cGMP and ISO-guided applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and ensure maximum shelf life. Isolate from incompatible materials such as strong bases, oxidizing agents, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.