Description

8-Bromo-CADP-ribose is a chemically modified nucleotide analog, specifically a brominated derivative of cyclic ADP-ribose (cADPR). This compound is a valuable biochemical tool and synthetic intermediate for research into calcium signaling pathways and nucleotide chemistry. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, biochemical research, and life science reagents.

Application

• Biochemical Research: As a potent and specific antagonist of cyclic ADP-ribose (cADPR) receptors, used to study intracellular calcium (Ca²⁺) signaling mechanisms.
• Enzyme Inhibition Studies: Investigation of ADP-ribosyl cyclase and CD38 enzyme activities and their roles in cellular processes.
• Pharmaceutical Intermediates: Serves as a key synthetic building block for developing novel therapeutics targeting calcium-related disorders.
• Cell Signaling Pathway Analysis: Tool compound for elucidating the role of cADPR in immune response, insulin secretion, and neuronal function.
• Reference Standard: Used as a high-purity analytical standard in quality control for related nucleotide products.
• Life Science Reagent Manufacturing: Incorporated into assay kits and research reagents sold to academic and industrial laboratories.

Basic Information

Product Name	8-Bromo-CADP-ribose
CAS No.	151898-26-9
Molecular Formula	C₁₇H₂₂BrN₅O₁₃P₂
Molecular Weight	670.24 g/mol
Synonyms	8-Bromo-cyclic ADP-ribose; 8-Br-cADPR; 8-Bromo-cyclic adenosine 5'-diphosphoribose; 8-Br-cADP-ribose; 8-Bromo-N⁶-(phosphoribosyl)-ADP; Cyclic 8-Bromoadenosine diphosphoribose; 8-Br-cyclic ADP-ribose antagonist
EINECS	Contact for details

Quality Control

Our 8-Bromo-CADP-ribose is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.