Description

Dmtr-Dh2U-Amidite CAS NO 151503-28-5 is a specialized phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. Its primary value lies in enabling the precise and efficient incorporation of modified nucleosides into DNA and RNA strands, which is essential for advanced research and therapeutic development. This high-purity reagent is indispensable for scientists and manufacturers in the fields of antisense therapeutics, diagnostic probe development, and synthetic biology, where sequence fidelity and functionalization are paramount.

Application

• Oligonucleotide Synthesis: Key monomer for the automated synthesis of DNA and RNA strands containing modified nucleobases.
• Antisense & siRNA Therapeutics: Production of research-grade and therapeutic oligonucleotides designed for gene silencing and targeted drug delivery.
• Diagnostic Probe Manufacturing: Creation of labeled probes for PCR, FISH, and microarray technologies requiring specific chemical modifications.
• Synthetic Biology & CRISPR: Construction of custom guide RNAs (gRNAs) and other functional nucleic acid components.
• Academic & Industrial R&D: Fundamental research in nucleic acid chemistry, structure-activity relationships, and novel biomaterial development.
• API Intermediate: Serves as a critical raw material in the cGMP production of oligonucleotide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Dmtr-Dh2U-Amidite
CAS No.	151503-28-5
Molecular Formula	C41H49N4O9P
Molecular Weight	772.82 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine, 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-Deoxy-2'-fluorouridine DMT phosphoramidite; 2'-F-dU Phosphoramidite; 2'-Fluoro-2'-deoxyuridine phosphoramidite; 5'-DMT-2'-F-dU-CE Phosphoramidite; Dh2U Amidite; 2'-F-dU-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our Dmtr-Dh2U-Amidite is manufactured under strict quality controls to meet the exacting standards of nucleic acid synthesis. Each batch is subjected to rigorous analytical testing, including HPLC, 31P NMR, and 1H NMR, to ensure chemical identity, purity, and stability. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 quality management principles, and we support customers requiring materials for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store in the original packaging.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.