Description

2'-o-Propargyladenosine is a chemically modified nucleoside derivative, specifically an adenosine analog featuring a propargyl group at the 2'-O position of the ribose sugar. This modification is critical for its primary role as a versatile building block in chemical biology and pharmaceutical research, enabling advanced applications through click chemistry. It is an essential reagent for researchers and manufacturers in the fields of nucleic acid chemistry, medicinal chemistry, and bioconjugation, where precise molecular tagging and functionalization are required.

Application

• Click Chemistry Reagent: Acts as a key substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for labeling and functionalizing biomolecules.
• Nucleic Acid Research: Used in the synthesis of modified oligonucleotides and probes for studying RNA structure, function, and metabolism.
• Medicinal Chemistry Intermediate: Serves as a precursor in the development of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Bioconjugation: Enables the site-specific attachment of fluorophores, affinity tags, or other functional groups to nucleic acids for diagnostics and imaging.
• Chemical Biology Tool Development: Employed in creating activity-based probes to study enzyme mechanisms and identify drug targets.
• Academic & Industrial R&D: Fundamental material for research institutions and pharmaceutical companies exploring novel nucleotide applications.

Basic Information

Product Name	2'-o-Propargyladenosine
CAS No.	151390-97-5
Molecular Formula	C13H15N5O4
Molecular Weight	305.29 g/mol
Synonyms	2'-O-Propargyladenosine; Adenosine, 2'-O-(2-propynyl)-; 2'-O-(2-Propynyl)adenosine; 2'-O-Propargyl-adenosine; 9-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)oxolan-2-yl)-9H-purin-6-amine; Propargyl Adenosine Derivative; Clickable Adenosine; 2'-O-Alkynyl Adenosine
EINECS	Contact for details

Quality Control

Our 2'-o-Propargyladenosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.