Description

Antafumicin A is a naturally derived antifungal macrolide metabolite isolated from Aspergillus fumigatus, recognized for its potent activity against filamentous fungi and yeast pathogens. It serves as a critical reference standard and pharmacological tool in antifungal drug discovery, mode-of-action studies, and resistance profiling. Research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) rely on high-purity Antafumicin A CAS NO 151271-54-4 for target validation, assay development, and mechanistic toxicology assessments.

Application

• Fungal target identification and pathway analysis in molecular mycology
• Reference standard for HPLC and LC-MS/MS quantification of antifungal metabolites
• Lead compound screening in antifungal drug discovery programs
• Mechanistic studies of mitochondrial complex III inhibition
• Development of antifungal susceptibility testing (AFST) panels
• Control material for quality assurance in natural product isolation workflows
• Structural biology applications including co-crystallization with cytochrome b
• Toxicity and selectivity profiling against mammalian cell lines

Basic Information

Product Name	Antafumicin A
CAS No.	151271-54-4
Molecular Formula	C35H51NO9
Molecular Weight	629.79 g/mol
Synonyms	Antafumicin A; AFM-A; Fumagillin-related macrolide A; Asperfumicin A; 35-Deoxyantafumicin A; Antafumicin I; NSC 678292; UNII-7QZ7X5T8VJ
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (HPLC retention time match, IR spectral overlay), purity (≥98.5% by HPLC-UV), and absence of microbial contamination. Testing follows ICH Q5A and USP General Chapter <1086> for reference standards, with full traceability to NIST-traceable controls.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep desiccated; avoid exposure to ambient humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Assay (HPLC-UV)	≥98.5%
Related Substances	≤1.0% total impurities (single impurity ≤0.3%)
Residual Solvents	Meets ICH Q3C limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.