Description

Cyclobutanecarbonyl Chloride, 1-(2-Fluorophenyl)- (9Ci) is a specialized fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in its unique bicyclic structure, which serves as a key precursor for constructing complex molecular architectures. This compound is primarily needed by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries, where it is utilized to introduce the cyclobutane-carbonyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the fluorophenyl and cyclobutane groups can enhance biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the research of specialty polymers with tailored thermal and mechanical properties.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial material supply.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 1-(2-Fluorophenyl)- (9Ci)
CAS No.	151157-31-2
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	1-(2-Fluorophenyl)cyclobutanecarbonyl chloride; 2-Fluoro-α-(1-oxocyclobutyl)benzeneacetyl chloride; 1-(2-Fluorophenyl)cyclobutane-1-carbonyl chloride; 1-(2-Fluorobenzyl)cyclobutanecarbonyl chloride (common misnomer); Cyclobutanecarbonyl chloride, 1-(2-fluorophenyl)-; 151157-31-2; 1-(o-Fluorophenyl)cyclobutanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 1-(2-Fluorophenyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development and commercial projects with specifications tailored to meet cGMP, ICH Q7, and ISO 9001 standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.