Description

5-Fluoro-2-Thio-2'-Deoxyuridylate is a modified nucleoside monophosphate analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and research tool for investigating nucleic acid metabolism and designing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery, as well as in the study of enzyme mechanisms and metabolic pathways.

Application

• Antiviral Research: Investigated as a potential precursor or active metabolite in the development of nucleoside analog-based antiviral therapies.
• Oncology Research: Used in studies targeting thymidylate synthase and other enzymes involved in DNA synthesis for potential anticancer applications.
• Biochemical Probe: Serves as a tool compound to study the function and inhibition of key enzymes in nucleotide metabolism.
• Pharmaceutical Intermediate: Acts as a sophisticated synthetic intermediate in the production of more complex nucleotide-based active pharmaceutical ingredients (APIs).
• Metabolic Pathway Analysis: Employed in research to trace and understand cellular metabolic pathways involving modified nucleotides.
• Enzyme Kinetics Studies: Utilized as a substrate or inhibitor in assays to determine enzyme activity and inhibition constants.

Basic Information

Product Name	5-Fluoro-2-Thio-2'-Deoxyuridylate
CAS No.	151134-50-8
Molecular Formula	C10H12FN2O8PS
Molecular Weight	370.25 g/mol
Synonyms	5-Fluoro-2-thio-2'-deoxyuridine 5'-monophosphate; 2'-Deoxy-5-fluoro-2-thiouridine 5'-monophosphate; 5-Fluoro-2-thio-dUMP; FdUMP-S; 5-Fluoro-2-thiouridylate; 2-Thio-5-fluoro-2'-deoxyuridylate; 5-Fluoro-2-thio-2'-deoxyuridylic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Thio-2'-Deoxyuridylate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures material suitable for demanding research applications, with the capability to meet custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.