Description

2-Bromo-3,4,5,6-Tetrafluorobenzoyl Chloride is a highly functionalized aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic combination of bromine and fluorine substituents, which enables precise structural modifications and the introduction of unique physicochemical properties into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty materials industries who require sophisticated intermediates for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer backbones, enhancing material properties like chemical resistance and low surface energy.
• Cross-Coupling Reactions: The bromine atom acts as a handle for further functionalization via palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig).
• Peptide & Protein Labeling: The reactive acid chloride group can be used to attach fluorinated aromatic probes to biomolecules for research and diagnostic applications.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluorobenzoyl Chloride
CAS No.	151096-42-3
Molecular Formula	C7BrClF4O
Molecular Weight	291.43 g/mol
Synonyms	2-Bromo-3,4,5,6-tetrafluorobenzoyl chloride; 3,4,5,6-Tetrafluoro-2-bromobenzoyl chloride; Benzoyl chloride, 2-bromo-3,4,5,6-tetrafluoro-; 2-Bromotetrafluorobenzoyl chloride; Tetrafluorobromobenzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-3,4,5,6-Tetrafluorobenzoyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support cGMP and ISO 9001 compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and strong acid/organic solvent nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.