Description

2'C-Methyladenosine 5'-Diphosphate is a chemically modified nucleotide analog of significant interest in biochemical and pharmaceutical research. This compound serves as a critical tool for studying enzyme kinetics, particularly for RNA polymerases and other nucleotide-dependent enzymes, due to its modified ribose moiety. It is primarily utilized by researchers and developers in pharmaceutical R&D, biotechnology, and academic laboratories for investigating viral replication mechanisms and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study the mechanisms of viral RNA-dependent RNA polymerases (RdRps), particularly for hepatitis C virus (HCV) and other flaviviruses.
• Antiviral Drug Discovery: Serves as a key intermediate or reference standard in the development and screening of nucleoside analog-based antiviral therapeutics.
• Enzyme Kinetics Studies: Employed to investigate the structure-activity relationships (SAR) and inhibition profiles of nucleotide-binding enzymes.
• Metabolic Pathway Analysis: Acts as a probe to understand cellular nucleotide metabolism and the incorporation of modified nucleotides into nucleic acids.
• Diagnostic Development: Potential use in the formulation of diagnostic kits for enzyme activity detection and high-throughput screening (HTS) platforms.

Basic Information

Product Name	2'C-Methyladenosine 5'-Diphosphate
CAS No.	150993-72-9
Molecular Formula	C11H16N5O10P2
Molecular Weight	464.22 g/mol
Synonyms	2'-C-Methyladenosine-5'-diphosphate; 2'-Methyl-ADP; 2'-C-Me-ADP; 2'-C-Methyl ADP; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[[hydroxy(phosphonooxy)phosphinyl]oxymethyl]-3-methyloxolan-2-yl]purin-6-amine; 2'-Methyladenosine 5'-(trihydrogen diphosphate); 2'-C-Methyladenosine diphosphate
EINECS	Contact for details

Quality Control

Every batch of 2'C-Methyladenosine 5'-Diphosphate is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including HPLC for purity and identity confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Assay	≥90% (anhydrous basis)
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.