Description

(S)-(-)-4-(N,n-Dimethylaminosulfonyl)-7-(2-Chloroformylpyrrolidin-1-Yl)Benzofurazan is a high-purity chiral benzofurazan derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its reactive chloroformyl group and chiral pyrrolidine moiety, enabling the precise construction of complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and sophisticated chemical probes.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, receptor antagonists, and other small-molecule drugs requiring specific stereochemical configurations.
• Agrochemical Research: Used in the synthesis of novel, optically active herbicides, fungicides, and plant growth regulators.
• Fluorescent Probe Synthesis: Acts as a precursor for creating advanced fluorescent labeling reagents and chemosensors due to the benzofurazan fluorophore core.
• Peptidomimetic Chemistry: Employed to introduce constrained, chiral pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with unique optical or chiral properties.
• Academic & Contract Research: A valuable tool for synthetic methodology development and exploring new chemical spaces in medicinal chemistry programs.

Basic Information

Product Name	(S)-(-)-4-(N,n-Dimethylaminosulfonyl)-7-(2-Chloroformylpyrrolidin-1-Yl)Benzofurazan
CAS No.	150993-63-8
Molecular Formula	C15H17ClN4O4S
Molecular Weight	384.84 g/mol
Synonyms	(S)-4-(N,N-Dimethylsulfamoyl)-7-(2-chlorocarbonylpyrrolidin-1-yl)-2,1,3-benzoxadiazole; (S)-7-(2-Chloroformyl-1-pyrrolidinyl)-4-(dimethylaminosulfonyl)-2,1,3-benzoxadiazole; (S)-DBD-COCl; (S)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole; (S)-4-(Dimethylsulfamoyl)-7-(2-chlorocarbonylpyrrolidin-1-yl)benzofurazan; (S)-Benzofurazan-7-(2-chloroformylpyrrolidine), 4-(dimethylaminosulfonyl)-; Chiral DBD-COCl derivative
EINECS	Contact for details

Quality Control

Our production of (S)-(-)-4-(N,n-Dimethylaminosulfonyl)-7-(2-Chloroformylpyrrolidin-1-Yl)Benzofurazan adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the reactive chloroformyl group. Handle and store in accordance with all applicable local regulations.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.