Description

8-Azidoguanosine Diphosphate-Glucose is a chemically modified nucleotide sugar analog, specifically designed as a bioorthogonal metabolic probe. This compound is critical for researchers investigating glycosylation pathways, glycan biosynthesis, and cellular metabolism through click chemistry-enabled labeling and detection. It is primarily utilized by biochemists, glycobiologists, and pharmaceutical R&D teams in the life sciences, biotechnology, and drug discovery sectors for advanced metabolic engineering and target identification studies.

Application

• Metabolic Glycan Labeling: Acts as a precursor for the metabolic incorporation of azide-tagged glucose into cellular glycans for subsequent visualization via click chemistry (e.g., with alkynes).
• Glycobiology Research: A key tool for studying the dynamics, trafficking, and function of glycoconjugates in live cells and organisms.
• Drug Discovery Target Validation: Used to identify and validate novel targets involved in carbohydrate metabolism and glycosylation disorders.
• Proteomics & Biomarker Discovery: Enables the enrichment and identification of azide-labeled glycoproteins and glycolipids from complex biological samples.
• Enzyme Activity Assays: Serves as a substrate analog for studying the activity and inhibition of glycosyltransferases and related enzymes.
• Chemical Biology Probe Development: Integral for developing new probes and techniques in chemical glycobiology and bioorthogonal chemistry.

Basic Information

Product Name	8-Azidoguanosine Diphosphate-Glucose
CAS No.	150518-47-1
Molecular Formula	C16H23N8O16P2
Molecular Weight	645.35 g/mol
Synonyms	8-N3-GDP-Glucose; 8-Azido-GDP-Glucose; GDP-8-Azidoguanosine-Glucose; Guanosine 5'-(trihydrogen diphosphate), P'→5'-ester with 8-azidoguanosine, 2'-(dihydrogen phosphate) 3'→β-D-glucopyranoside; 8-Azido-guanosine diphosphoglucose; Azido-GDP-Glc; Metabolic probe for glycosylation
EINECS	Contact for details

Quality Control

Our 8-Azidoguanosine Diphosphate-Glucose is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with research-grade or higher standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.