Description

8-Azido-Cyclic Adenosine Diphosphate-Ribose (8-Azido-cADPR) is a chemically modified, photoaffinity analog of the endogenous calcium-mobilizing second messenger, cyclic ADP-ribose (cADPR). This compound is a critical research tool for investigating calcium signaling pathways, specifically for identifying and characterizing cADPR receptors and binding proteins. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on cell biology, neurobiology, and cardiovascular physiology.

Application

• Photoaffinity Labeling Studies: Acts as a molecular probe to covalently tag and identify cADPR receptor proteins (e.g., ryanodine receptors) in complex biological samples upon UV irradiation.
• Calcium Signaling Research: Used to elucidate the role of cADPR-mediated pathways in various cellular processes, including muscle contraction, neurotransmitter release, and immune cell activation.
• Mechanism of Action Studies: Employed in competitive binding assays to study the interaction between cADPR and its target proteins, helping to define binding sites and affinities.
• Drug Discovery Screening: Serves as a reference compound and probe in high-throughput screens to identify novel modulators of the cADPR signaling pathway for therapeutic intervention.
• Biochemical Assay Development: Used as a standard or tracer in the development of sensitive assays (e.g., radiometric or fluorescent) for cADPR quantification and receptor analysis.

Basic Information

Product Name	8-Azido-Cyclic Adenosine Diphosphate-Ribose
CAS No.	150424-94-5
Molecular Formula	C15H20N8O12P2
Molecular Weight	566.32 g/mol
Synonyms	8-Azido-cADPR; 8-N3-cADPR; Cyclic 8-Azidoadenosine Diphosphoribose; 8-Azidocyclic ADP-ribose; 8-N3-Cyclic Adenosine 5'-Diphosphoribose; Photo-cADPR; cADPR azide analog; Adenosine, cyclic 8-azido-
EINECS	Contact for details

Quality Control

Our 8-Azido-cADPR is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and structural confirmation via mass spectrometry (MS) and NMR. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.