Description

1H-Indene,2,3-Dihydro-5-Isothiocyanato-(9Ci) is a specialized organic building block containing a reactive isothiocyanate functional group. This compound matters for its role as a key intermediate in the synthesis of more complex heterocyclic molecules and active pharmaceutical ingredients (APIs). It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic indene core.
• Chemical Biology Probe Development: The reactive isothiocyanate group allows for covalent conjugation to biomolecules, useful in creating probes for target identification and validation.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex indene-derived scaffolds and heterocycles.
• Ligand Synthesis for Catalysis: Utilized to prepare novel ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	1H-Indene,2,3-Dihydro-5-Isothiocyanato-(9Ci)
CAS No.	149865-84-9
Molecular Formula	C10H7NS
Molecular Weight	173.23 g/mol
Synonyms	5-Isothiocyanato-2,3-dihydro-1H-indene; 2,3-Dihydro-1H-indene-5-yl isothiocyanate; 5-Indanyl isothiocyanate; 1H-Indene, 2,3-dihydro-5-isothiocyanato-; 149865-84-9; 5-Isothiocyanatoindane; Indan-5-yl isothiocyanate
EINECS	Contact for details

Quality Control

Our 1H-Indene,2,3-Dihydro-5-Isothiocyanato-(9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. Due to the reactive nature of the isothiocyanate group, containers should be kept tightly sealed under an inert atmosphere for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.