Description

1-Acetyl-4-(4-Hydroxyphenyl)Piperidineketoconazole is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs), particularly in specialized therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the synthesis of complex molecules for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry: Serves as a key starting material (KSM) or intermediate in scaling up synthetic routes from laboratory to pilot and commercial production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.
• Reference Standard: Utilized as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	1-Acetyl-4-(4-Hydroxyphenyl)Piperidineketoconazole
CAS No.	149354-13-2
Molecular Formula	C24H25FN2O4
Molecular Weight	424.47 g/mol
Synonyms	1-Acetyl-4-(4-hydroxyphenyl)piperidine ketoconazole; 4-(4-Hydroxyphenyl)-1-acetylpiperidine ketoconazole; Ketoconazole piperidine derivative; 1-[4-(4-Hydroxyphenyl)-1-piperidinyl]ethanone ketoconazole; (2R,4S)-2-(1H-Imidazol-1-ylmethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl 4-[4-(4-hydroxyphenyl)-1-piperidinyl]phenyl methanone; 149354-13-2; Ketoconazole intermediate
EINECS	Contact for details

Quality Control

Our 1-Acetyl-4-(4-Hydroxyphenyl)Piperidineketoconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which is available for every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.