Description

2-Bromo-2,2-Difluoro-1-Morpholin-4-Yl-Ethanone is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role as a key reagent in the introduction of difluoromethyl and gem-difluoroalkyl motifs, which are crucial for modulating the physicochemical and metabolic properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethylene (CF2) groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing fluorinated polymers and advanced materials with unique surface properties and chemical resistance.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and scaffold modification to explore structure-activity relationships (SAR) in drug candidate libraries.
• Fluorine Chemistry Reagent: Acts as a versatile electrophilic difluoromethylating agent in various name reactions and novel synthetic methodologies.

Basic Information

Product Name	2-Bromo-2,2-Difluoro-1-Morpholin-4-Yl-Ethanone
CAS No.	149229-27-6
Molecular Formula	C6H8BrF2NO2
Molecular Weight	240.04 g/mol
Synonyms	2-Bromo-2,2-difluoro-1-(morpholin-4-yl)ethanone; 2-Bromo-2,2-difluoro-1-(4-morpholinyl)-1-ethanone; 4-(2-Bromo-2,2-difluoroacetyl)morpholine; Morpholine, 4-(2-bromo-2,2-difluoroacetyl)-; 2-Bromo-2,2-difluoro-1-(morpholino)ethanone; α-Bromo-α,α-difluoro-4-morpholineacetophenone; Difluorobromoacetyl morpholine
EINECS	Contact for details

Quality Control

Our 2-Bromo-2,2-Difluoro-1-Morpholin-4-Yl-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.