Description

1-(1'-Cyanoribofuranosyl)Thymine CAS NO 149228-60-4 is a modified nucleoside derivative, a key building block in advanced oligonucleotide synthesis and medicinal chemistry research. This compound is essential for developing novel therapeutic agents, particularly in the fields of antisense oligonucleotides and siRNA, where precise chemical modification is critical for stability and efficacy. It serves as a vital raw material for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on next-generation nucleic acid-based therapeutics and diagnostics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of modified oligonucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate specific modifications that enhance nuclease resistance and target binding affinity.
• siRNA and RNAi Therapeutics: Serves as a building block for chemically modified siRNA strands to improve pharmacokinetic properties.
• Medicinal Chemistry & Drug Discovery: Employed in research to explore structure-activity relationships (SAR) of nucleoside analogs.
• Diagnostic Probe Synthesis: Utilized in creating labeled nucleic acid probes for molecular diagnostics and bioanalytical assays.
• Bioconjugation and Labeling: The cyanoribofuranosyl moiety can be leveraged for further chemical derivatization and conjugation.

Basic Information

Product Name	1-(1'-Cyanoribofuranosyl)Thymine
CAS No.	149228-60-4
Molecular Formula	C11H13N3O6
Molecular Weight	283.24 g/mol
Synonyms	1-(1'-Cyanoribofuranosyl)thymine; 1-(1-Cyano-β-D-ribofuranosyl)thymine; 1-(1-Cyano-β-D-ribofuranosyl)thymine; Thymine, 1-(1-cyano-β-D-ribofuranosyl)-; 1-(1-Cyano-β-D-ribofuranosyl)-5-methyluracil; 1'-Cyanothymidine; CN-Thd; 1-(1'-CN-ribofuranosyl)thymine
EINECS	Contact for details

Quality Control

Our 1-(1'-Cyanoribofuranosyl)Thymine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.