Description

7-Ethyl-2'-Deoxyguanosine-3'-Monophosphate is a chemically modified nucleoside monophosphate, a critical building block for advanced oligonucleotide synthesis. This compound matters for its role in creating modified DNA strands with enhanced properties for research and therapeutic applications. It is primarily needed by biotechnology and pharmaceutical companies engaged in antisense therapy development, diagnostic probe manufacturing, and fundamental biochemical research.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Used as a modified nucleotide precursor to incorporate ethyl modifications, enhancing nuclease resistance and binding affinity of therapeutic oligonucleotides.
• Diagnostic Probe Development: Serves as a key raw material in the production of labeled probes for genetic testing, PCR, and hybridization assays.
• Biochemical Research: Employed in studying DNA repair mechanisms, enzyme-substrate interactions, and the structural impact of base alkylation.
• Pharmaceutical Intermediate: Acts as a crucial intermediate in the synthesis of novel nucleoside-based antiviral or anticancer prodrug candidates.
• Synthetic Biology: Utilized to engineer DNA with altered physical or chemical properties for novel biosensors or genetic circuits.

Basic Information

Product Name	7-Ethyl-2'-Deoxyguanosine-3'-Monophosphate
CAS No.	149206-55-3
Molecular Formula	C12H18N5O7P
Molecular Weight	375.27 g/mol
Synonyms	7-Ethyl-dGMP; 7-Ethyl-2'-deoxyguanosine 3'-monophosphate; 7-Ethyl-2'-deoxy-GMP; 2'-Deoxy-7-ethylguanosine 3'-monophosphate; 7-Ethyl-2'-deoxyguanosine 3'-(dihydrogen phosphate); dG(7Et)MP; 7-Ethyl-2'-deoxyguanosine-3'-phosphate
EINECS	Contact for details

Quality Control

Our 7-Ethyl-2'-Deoxyguanosine-3'-Monophosphate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and MS. We support compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.