Description

1-(Trimethylsilyl)-3,5-Difluorobenzene is a high-purity organosilicon intermediate featuring a benzene ring substituted with fluorine and a trimethylsilyl protecting group. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluorobenzene moiety imparts specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive silicon-aryl bond.
• Protecting Group Chemistry: The trimethylsilyl group can be used to protect reactive sites during multi-step synthetic sequences.
• Material Science Research: Employed in the development of novel polymers and advanced materials with tailored thermal and electronic properties.

Basic Information

Product Name	1-(Trimethylsilyl)-3,5-Difluorobenzene
CAS No.	149130-47-2
Molecular Formula	C9H12F2Si
Molecular Weight	186.28 g/mol
Synonyms	3,5-Difluorophenyltrimethylsilane; Trimethyl(3,5-difluorophenyl)silane; (3,5-Difluorophenyl)trimethylsilane; 3,5-Difluoro-1-(trimethylsilyl)benzene; Benzene, 1-(trimethylsilyl)-3,5-difluoro-; TMS-3,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.