Description

Fmoc-Asp(Obzl)-Cl CAS NO 148827-71-8 is a protected amino acid derivative, specifically an Fmoc-protected aspartic acid benzyl ester activated as an acid chloride. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of aspartic acid into peptide chains. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected, side-chain protected amino acid chloride for the automated or manual synthesis of peptides.
• Pharmaceutical Research: For the development and production of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Used to introduce aspartic acid residues or reactive handles into proteins, antibodies, or other biomolecules for conjugation purposes.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and high-throughput screening.
• Academic Research: Employed in university and institutional labs for studying peptide structure, function, and synthesis methodologies.
• Fine Chemical Synthesis: As an intermediate in the multi-step synthesis of complex organic compounds requiring protected aspartic acid moieties.

Basic Information

Product Name	Fmoc-Asp(Obzl)-Cl
CAS No.	148827-71-8
Molecular Formula	C26H22ClNO5
Molecular Weight	463.91 g/mol
Synonyms	Fmoc-L-aspartic acid 4-benzyl ester chloride; N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid β-benzyl ester chloride; Fmoc-Asp-OBzl-Cl; Fmoc-Asp(OBzl)-OH chloride; (2S)-4-Benzyl 1-[(9H-fluoren-9-ylmethoxy)carbonylamino]-1,4-dioxobutane-2-carboxylate chloride; N-α-Fmoc-L-aspartic acid β-benzyl ester acid chloride; Fmoc-Asp(OBn)-Cl
EINECS	Contact for details

Quality Control

Our Fmoc-Asp(Obzl)-Cl is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory requirements for research and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) in a freezer (-20°C). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.