Description

5-Ethyl-4-Thiouridine is a modified nucleoside analog, specifically a thiolated derivative of uridine. This compound is of significant interest in biochemical and pharmaceutical research due to its unique structure, which can influence nucleic acid stability and function. It serves as a critical building block and research tool for scientists in nucleic acid chemistry, medicinal chemistry, and drug discovery, particularly in the development of novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating RNA structure, function, and thiol-modification impacts on nucleic acid behavior.
• Probe Development: Serves as a precursor for creating labeled nucleotides used in diagnostic assays and molecular biology techniques.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Academic & Industrial R&D: Fundamental research material in laboratories focused on nucleotide chemistry and related life sciences.

Basic Information

Product Name	5-Ethyl-4-Thiouridine
CAS No.	148744-32-5
Molecular Formula	C11H16N2O5S
Molecular Weight	288.32 g/mol
Synonyms	4-Thio-5-ethyluridine; 5-Ethyl-4-thiouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethyl-2,4(1H,3H)-pyrimidinedithione; 4-Thio-5-ethyl-uridine; 5-Ethyl-2,4-dithioxo-1,2,3,4-tetrahydropyrimidine-1-riboside
EINECS	Contact for details

Quality Control

Our 5-Ethyl-4-Thiouridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.