Description

Archaeosine CAS NO 148608-52-0 is a modified nucleoside, specifically a 7-deazaguanosine derivative, that serves as a critical building block in the study of transfer RNA (tRNA) structure and function. Its primary value lies in enabling advanced biochemical research into the mechanisms of translation and RNA modification, which are fundamental to understanding genetic regulation and developing novel therapeutics. This high-purity biochemical is essential for researchers and manufacturers in the fields of life science research, pharmaceutical development, and diagnostic assay production.

Application

• Biochemical Research: A key substrate for studying the biosynthesis and function of the hypermodified nucleoside archaeosine (G+) found in the D-loop of archaeal and some eukaryotic tRNAs.
• Enzymology Studies: Used as a standard or precursor in assays for tRNA-guanine transglycosylase (TGT) and other modifying enzymes to investigate catalytic mechanisms and inhibition.
• Pharmaceutical Development: Serves as a reference compound or synthetic intermediate in the discovery of novel antibiotics and antiviral agents that target unique tRNA modification pathways in pathogens.
• Diagnostic Reagent Manufacturing: Incorporated into specialized kits and reagents for the detection and quantification of specific tRNA modifications linked to cellular stress or disease states.
• Synthetic Biology: Used in the engineering of synthetic tRNA molecules with enhanced stability or novel functions for therapeutic and industrial applications.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring molecular biology, genetics, and the evolution of the translation apparatus.

Basic Information

Product Name	Archaeosine
CAS No.	148608-52-0
Molecular Formula	C₁₇H₂₃N₅O₆
Molecular Weight	393.40 g/mol
Synonyms	7-Cyano-7-deazaguanosine; 7-Cyano-7-carbaguanosine; PreQ0 nucleoside; 7-Deaza-7-cyanoguanosine; 2-Amino-5-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]amino]-7-cyano-3H-pyrrolo[2,3-d]pyrimidin-4-one; Archaeosine precursor; G+ precursor nucleoside
EINECS	Contact for details

Quality Control

Our Archaeosine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.