Description

O6-Benzyl-N2,3-Etheno-2'-Deoxy-3',5'-o-[Tetrakis(Isopropyl)-1,3-Disiloxanediyl] Guanosine is a sophisticated, protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks to create stable and specific nucleic acid sequences. It is primarily utilized in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids, serving the pharmaceutical, biotechnology, and advanced life science research sectors.

Application

• Solid-Phase Oligonucleotide Synthesis: Acts as a key protected phosphoramidite precursor for the automated synthesis of modified DNA/RNA strands.
• Antisense Therapeutic Development: Used in the research and production of antisense oligonucleotides (ASOs) designed for targeted gene silencing.
• siRNA and miRNA Synthesis: Serves as a crucial intermediate for constructing small interfering RNA (siRNA) and microRNA (miRNA) analogs with enhanced nuclease resistance.
• Diagnostic Probe Fabrication: Employed in creating labeled and modified nucleic acid probes for diagnostic assays and genomic research.
• Medicinal Chemistry & Drug Discovery: Provides a versatile scaffold for exploring structure-activity relationships in nucleoside-based drug candidates.
• Academic & Industrial Research: Supports fundamental research in nucleic acid chemistry, biochemistry, and molecular biology.

Basic Information

Item	Details
Product Name	O6-Benzyl-N2,3-Etheno-2'-Deoxy-3',5'-o-[Tetrakis(Isopropyl)-1,3-Disiloxanediyl] Guanosine
CAS No.	148437-94-9
Molecular Formula	C35H53N5O6Si2
Molecular Weight	708.01 g/mol
Synonyms	1-[2-Deoxy-3,5-O-[1,1,3,3-tetraisopropyl-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]-N2,3-etheno-O6-benzylguanine; O6-Bn-N2,3-Etheno-dG(TIPDS); 2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-O6-benzyl-N2,3-ethenoguanosine; N2,3-Etheno-O6-benzyl-2'-deoxyguanosine 3',5'-bis(TIPDS) ether; Protected Ethenoguanosine Derivative; TIPDS-protected O6-Bn-N2,3-etheno-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for sensitive pharmaceutical applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.