Description

4-(4-Methylpiperazin-1-Ylmethyl)Benzoyl Chloride is a high-purity, reactive benzoyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the functionalized piperazine-methyl-benzoyl scaffold, which is essential for constructing complex molecules with targeted biological activity. This intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and receptor antagonists.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final or penultimate steps of manufacturing complex APIs.
• Bioconjugation & Probe Development: The reactive acid chloride group enables coupling to amines, alcohols, or other nucleophiles for creating biochemical probes or antibody-drug conjugates (ADC) linkers.
• Agrochemical Research: Intermediate in the development of new generation herbicides and fungicides with specific mode-of-action.
• Material Science: Monomer or cross-linking agent for the synthesis of specialized polymers with unique thermal or mechanical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	4-(4-Methylpiperazin-1-Ylmethyl)Benzoyl Chloride
CAS No.	148077-69-4
Molecular Formula	C14H19ClN2O
Molecular Weight	266.77 g/mol
Synonyms	4-[(4-Methyl-1-piperazinyl)methyl]benzoyl chloride; 4-(4-Methylpiperazin-1-ylmethyl)benzoyl chloride; 1-[[4-(Chlorocarbonyl)phenyl]methyl]-4-methylpiperazine; 4-(4-Methylpiperazine-1-ylmethyl)benzoic acid chloride; p-[(4-Methyl-1-piperazinyl)methyl]benzoyl chloride; 4-(N-Methylpiperazinomethyl)benzoyl chloride; Benzoyl chloride, 4-[(4-methyl-1-piperazinyl)methyl]-
EINECS	Contact for details

Quality Control

Our 4-(4-Methylpiperazin-1-Ylmethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.