Description

2-Fluoro-4-Hydroxyestradiol is a fluorinated derivative of the endogenous estrogen hormone estradiol, designed for advanced research and development applications. This compound is valued for its utility as a biochemical tool in studying estrogen receptor interactions and metabolic pathways. It is primarily used by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in endocrinology, oncology, and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or reference standard in the development of novel steroid-based therapeutics.
• Biochemical Research: Used as a probe to investigate the structure-activity relationships (SAR) of estrogen receptor ligands and their metabolic fate.
• Metabolic Studies: Employed in in vitro and in vivo studies to understand the hydroxylation and fluorination effects on steroid hormone activity and clearance.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Endocrine Disruptor Research: Utilized in environmental and toxicological studies to assess the impact of fluorinated steroids.

Basic Information

Item	Details
Product Name	2-Fluoro-4-Hydroxyestradiol
CAS No.	148044-31-9
Molecular Formula	C18H23FO3
Molecular Weight	306.37 g/mol
Synonyms	2-Fluoroestra-1,3,5(10)-triene-3,4,17β-triol; 2-Fluoro-4,17β-dihydroxyestra-1,3,5(10)-trien-3-ol; 2-Fluoro-4-hydroxy-17β-estradiol; 4-Hydroxy-2-fluoroestradiol; 2-F-4-OHE2
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxyestradiol is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.