Description

Doripenem is a broad-spectrum carbapenem antibiotic belonging to the β-lactam class, valued for its potent activity against a wide range of Gram-positive and Gram-negative bacteria, including many multi-drug resistant strains. Its primary commercial value lies in its critical role as an active pharmaceutical ingredient (API) for formulating injectable antibacterial medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for serious hospital-acquired infections, such as complicated intra-abdominal infections and complicated urinary tract infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Hospital Infection Treatment: Formulated for treating complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI).
• Antibacterial Research: Serves as a key reference standard and intermediate in antimicrobial research and development.
• Generic Drug Manufacturing: Critical for producers of generic injectable carbapenem antibiotics.
• Clinical Study Material: Used in bioequivalence and pharmacokinetic studies for new drug applications.
• Veterinary Pharmaceutical Development: Potential application in developing antibacterial treatments for animal health.

Basic Information

Product Name	Doripenem
CAS No.	148016-81-3
Molecular Formula	C15H24N4O6S2
Molecular Weight	420.50 g/mol
Synonyms	Doripenem Monohydrate; S-4661; (4R,5S,6S)-3-[[(3S,5S)-5-[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; Finibax; Doribax; Carbapenem Antibiotic S-4661
EINECS	Contact for details

Quality Control

Our Doripenem is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical API applications. Quality is assured through rigorous in-process controls and comprehensive final testing, which includes identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing results against relevant pharmacopeial standards (such as USP or in-house specifications) is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	< 0.05 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.