Description

2H-Thiopyran-2-Carbonyl Chloride, Tetrahydro- (9Ci) is a versatile and highly reactive organosulfur building block, specifically a cyclic thiopyran-derived acid chloride. Its core value proposition lies in its ability to efficiently introduce the tetrahydrothiopyran-2-carbonyl moiety into target molecules, enabling the synthesis of complex sulfur-containing compounds with potential biological activity. This intermediate is particularly valuable for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel active ingredients, where sulfur heterocycles are a privileged scaffold.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of potential drug candidates, especially those targeting neurological disorders, metabolic diseases, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate sulfur heterocycles for enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic materials, such as polymers and liquid crystals, with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: An essential building block for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for client projects.

Basic Information

Product Name	2H-Thiopyran-2-Carbonyl Chloride, Tetrahydro- (9Ci)
CAS No.	147164-54-3
Molecular Formula	C6H7ClOS
Molecular Weight	162.63 g/mol
Synonyms	Tetrahydro-2H-thiopyran-2-carbonyl chloride; Tetrahydro-2H-thiopyran-2-carboxylic acid chloride; Perhydrothiopyran-2-carbonyl chloride; 2-Thiopyrancarbonyl chloride, tetrahydro-; 2-Carboxytetrahydrothiopyran chloride; Tetrahydrothiopyran-2-carbonyl chloride; 147164-54-3; Tetrahydro-2H-thiopyrane-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2H-Thiopyran-2-Carbonyl Chloride, Tetrahydro- (9Ci) is produced and analyzed under strict quality management protocols. We ensure high purity and lot-to-lot consistency through comprehensive analytical techniques including NMR, HPLC, and GC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.