Description

Cytidine, n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxy-2'-Fluoro- is a sophisticated, protected nucleoside derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in the synthesis of modified oligonucleotides, enabling the development of novel therapeutic and diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key protected monomer in the solid-phase synthesis of fluorinated oligonucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Research: Used to incorporate 2'-fluoro-2'-deoxycytidine analogs into oligonucleotide sequences to enhance nuclease resistance and binding affinity.
• siRNA and miRNA Synthesis: Employed in the preparation of chemically modified small interfering RNA (siRNA) and microRNA (miRNA) strands to improve stability and pharmacokinetic properties.
• Diagnostic Probe Development: Acts as a precursor for labeled nucleosides used in fluorescent or radioactive probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry & Drug Discovery: Serves as a scaffold for exploring structure-activity relationships (SAR) in nucleoside-based drug candidates targeting viral infections or cancers.
• Academic & Industrial R&D: A valuable reagent for university laboratories and biotech R&D departments studying nucleic acid chemistry and modification.

Basic Information

Item	Detail
Product Name	Cytidine, n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxy-2'-Fluoro-
CAS No.	146954-77-0
Molecular Formula	C37H33FN2O7
Molecular Weight	636.67 g/mol
Synonyms	5'-O-DMT-2'-Fluoro-2'-deoxy-N4-benzoylcytidine; 2'-Fluoro-2'-deoxy-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)cytidine; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-N4-benzoylcytidine; N4-Benzoyl-5'-O-DMT-2'-deoxy-2'-fluorocytidine; DMT-2'-F-dC(Bz) Phosphoramidite precursor; 2'-F-dC(Bz) DMT; Protected 2'-Fluorocytidine derivative
EINECS	Contact for details

Quality Control

Every batch of Cytidine, n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxy-2'-Fluoro- is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity suitable for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (argon or nitrogen) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.