Description

Dactylfungin B CAS NO 146935-36-6 is a specialized antifungal compound belonging to the echinocandin class, which targets the synthesis of β-(1,3)-D-glucan in fungal cell walls. This mechanism of action makes it a critical agent for research and development in combating serious fungal infections. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on developing novel antifungal therapies and studying fungal resistance mechanisms.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new systemic antifungal drugs.
• Mechanism of Action Studies: Used in biochemical and microbiological assays to investigate the inhibition of β-(1,3)-D-glucan synthase and fungal cell wall biosynthesis.
• Antifungal Susceptibility Testing: Employed as a control compound to assess the efficacy of new drug candidates and to study emerging fungal resistance patterns.
• Preclinical Studies: Utilized in *in vitro* and *in vivo* models to evaluate pharmacokinetics, pharmacodynamics, and toxicology profiles of echinocandin-based therapies.
• Process Chemistry & Synthesis: Acts as a crucial intermediate or starting material for the synthetic preparation of more complex echinocandin derivatives and analogs.

Basic Information

Product Name	Dactylfungin B
CAS No.	146935-36-6
Molecular Formula	C52H81N7O17
Molecular Weight	1052.2 g/mol
Synonyms	Dactylfungin B; FR901379; (4R,5R)-4,5-Dihydroxy-N2-[(1S,2S)-1-hydroxy-2-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-L-ornithyl-L-threonyl-trans-3-hydroxy-L-prolyl-(S)-4-hydroxyhomotyrosyl-(2S,3S)-3-hydroxy-2-aminobutanoyl-(3S)-3-hydroxy-L-homotyrosyl-1,2,3,4,6,11-hexahydro-11-oxopyrido[2,1-b]quinazoline-8-carboxamide; Echinocandin B derivative; FR 901379
EINECS	Contact for details

Quality Control

Our Dactylfungin B is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.