Description

Dactylfungin A is a potent antifungal compound belonging to the echinocandin class, known for its targeted inhibition of fungal cell wall synthesis. This high-purity reference standard is critical for pharmaceutical research, quality control, and analytical method development. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in antifungal drug discovery and development.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of antifungal APIs and finished drug products.
• Biochemical Research: Serves as a key tool in studies of fungal cell wall biosynthesis, mechanism of action, and resistance profiling.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and other chromatographic methods for potency and purity testing.
• Quality Control & Assurance: Employed in in-process testing and release testing of antifungal active pharmaceutical ingredients (APIs).
• Microbiology Studies: Used to determine minimum inhibitory concentrations (MICs) and evaluate the efficacy of antifungal agents against various fungal strains.

Basic Information

Product Name	Dactylfungin A
CAS No.	146935-35-5
Molecular Formula	C52H81N7O17
Molecular Weight	1052.2 g/mol
Synonyms	Dactylfungin; FR901379; (4R,5R)-4,5-Dihydroxy-N2-[(1E,3E,5E,7E)-9-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-1-(hydroxymethyl)-9-oxonona-1,3,5,7-tetraen-1-yl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(4R)-4-hydroxy-L-prolyl-(2S)-2-amino-6-hydroxyhexanoyl-(4R)-4,8-diamino-8-oxooctanoyl-(3S)-3-hydroxy-L-prolinamide; Echinocandin derivative FR901379
EINECS	Contact for details

Quality Control

Our Dactylfungin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure compliance with research-grade standards. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under dry, inert conditions to maintain stability and prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.