Description

n-(1-Naphthalenesulfonyl)-L-Phenylalanyl Chloride is a specialized amino acid derivative and activated ester used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for constructing complex peptide chains. It is primarily utilized in pharmaceutical research, process development, and the production of active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Peptide Synthesis Intermediate: Acts as a crucial activated amino acid derivative for solid-phase and solution-phase peptide coupling reactions.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide drugs and bioactive compounds.
• API Manufacturing: Serves as a building block in the commercial-scale synthesis of peptide-based Active Pharmaceutical Ingredients.
• Bioconjugation: Employed in the chemical modification of proteins and other biomolecules for therapeutic or diagnostic applications.
• Protease Inhibitor Synthesis: A key precursor in the synthesis of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Probes: Utilized to create labeled or tagged peptides for studying biological mechanisms and pathways.

Basic Information

Product Name	n-(1-Naphthalenesulfonyl)-L-Phenylalanyl Chloride
CAS No.	146864-62-2
Molecular Formula	C20H16ClNO3S
Molecular Weight	385.86 g/mol
Synonyms	N-1-Naphthalenesulfonyl-L-phenylalanyl chloride; NSC 405122; L-Phenylalanine, N-[(1-naphthalenylsulfonyl)]-, chloride; 1-Naphthalenesulfonamide, N-[(2S)-1-chloro-1-oxo-3-phenyl-2-propanyl]-; N-(1-Naphthylsulfonyl)-L-phenylalanyl chloride; Naphthalene-1-sulfonyl-L-phenylalanyl chloride; Ns-Phe-Cl
EINECS	Contact for details

Quality Control

Our n-(1-Naphthalenesulfonyl)-L-Phenylalanyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.