Description

n-(4-Nitrophenylsulfonyl)-L-Phenylalanyl Chloride is a specialized, high-purity chemical building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific modifications in peptide and small molecule development. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery, proteomics, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Proteomics Research: Used as a chemical probe or labeling agent for studying protein structure, function, and interactions.
• Solid-Phase Peptide Synthesis (SPPS): Acts as an activated amino acid derivative for the controlled, sequential assembly of peptides.
• Bioconjugation: Facilitates the covalent attachment of peptides or other molecules to carriers, surfaces, or biomolecules.
• Library Synthesis: Employed in combinatorial chemistry for generating diverse compound libraries for high-throughput screening.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	n-(4-Nitrophenylsulfonyl)-L-Phenylalanyl Chloride
CAS No.	146815-23-8
Molecular Formula	C21H17ClN2O6S
Molecular Weight	460.89 g/mol
Synonyms	NSC 339587; L-Phenylalanine, N-[(4-nitrophenyl)sulfonyl]-, chloride; 4-Nitrobenzenesulfonyl-L-phenylalanyl chloride; (2S)-2-[(4-Nitrobenzenesulfonyl)amino]-3-phenylpropanoyl chloride; Phenylalanyl chloride, N-(4-nitrophenylsulfonyl)-, L-; N-(4-Nitrobenzenesulfonyl)-L-phenylalanine acid chloride; N-Phenylalanyl chloride, N-(4-nitrophenylsulfonyl)-
EINECS	Contact for details

Quality Control

Our n-(4-Nitrophenylsulfonyl)-L-Phenylalanyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.