Description

Ethyl 4-(Chlorocarbonyl)-1-Piperidinecarboxylate is a versatile and high-purity piperidine derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a chloroformyl group and a protected amine, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing the piperidine scaffold, such as central nervous system (CNS) agents and receptor modulators.
• Peptide Mimetics & PROTACs: Used to incorporate piperidine-based linkers and structural elements into peptide mimetics and Proteolysis Targeting Chimeras (PROTACs) for drug discovery.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Employed in the research and development of specialty polymers, coatings, and advanced materials requiring specific functional groups.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams for exploring new synthetic routes and creating custom compound libraries.

Basic Information

Product Name	Ethyl 4-(Chlorocarbonyl)-1-Piperidinecarboxylate
CAS No.	146801-00-5
Molecular Formula	C9H14ClNO3
Molecular Weight	219.66 g/mol
Synonyms	1-(Ethoxycarbonyl)-4-piperidinecarbonyl chloride; Ethyl 4-(chloroformyl)piperidine-1-carboxylate; 4-(Chlorocarbonyl)-1-piperidinecarboxylic Acid Ethyl Ester; 1-Carbethoxy-4-piperidinecarbonyl chloride; Piperidine-1,4-dicarboxylic acid ethyl ester chloride; 4-Carboxy-1-piperidinecarboxylic acid ethyl ester chloride; 1-Piperidinecarboxylic acid, 4-(chlorocarbonyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Chlorocarbonyl)-1-Piperidinecarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.