Description

2-(n-Iodoacetylaminoethyl)Thioadenine is a specialized biochemical reagent featuring a reactive iodoacetyl group linked to an adenine derivative. This compound is a critical intermediate for the site-specific modification of biomolecules, particularly in the development of targeted probes and conjugates. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require precise labeling and cross-linking capabilities.

Application

• Bioconjugation & Probe Synthesis: A key reagent for the covalent attachment of labels, drugs, or other molecules to proteins, peptides, or nucleic acids via thiol-reactive chemistry.
• Pharmaceutical Research: Used in the synthesis of targeted drug conjugates, such as antibody-drug conjugates (ADCs), for oncology and other therapeutic areas.
• Diagnostic Development: Serves as an intermediate in creating enzyme-linked or fluorescently labeled probes for immunoassays and molecular diagnostics.
• Chemical Biology & Proteomics: Employed in activity-based protein profiling (ABPP) and other studies to tag and identify active-site residues in enzymes.
• Biomaterial Functionalization: Used to modify surfaces or polymers with adenine-based ligands for biosensor or tissue engineering applications.
• Nucleic Acid Research: Acts as a modified nucleobase precursor for the synthesis of functionalized oligonucleotides with reactive handles.

Basic Information

Product Name	2-(n-Iodoacetylaminoethyl)Thioadenine
CAS No.	146269-93-4
Molecular Formula	C12H14IN7OS
Molecular Weight	447.25 g/mol
Synonyms	N-[2-(6-Amino-9H-purin-9-yl)ethyl]-2-iodoacetamide; 2-(2-Iodoacetamidoethyl)thioadenine; 6-Amino-9-[2-[(iodoacetyl)amino]ethyl]-9H-purine; 9-[2-[(Iodoacetyl)amino]ethyl]adenine; Iodoacetyl Amidoethyl Thioadenine; Iodoacetamidoethylthioadenine
EINECS	Contact for details

Quality Control

Our production of 2-(n-Iodoacetylaminoethyl)Thioadenine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.