Description

1H-Imidazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci) is a high-value, multi-functional chemical building block characterized by its reactive carbonyl chloride group and cyano-substituted imidazole core. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand and Catalyst Development: Serves as a versatile building block for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and functional materials with tailored electronic or photonic properties.
• Bioconjugation and Probe Synthesis: Useful for creating fluorescent probes, affinity labels, and other biochemical tools due to its reactive acyl chloride moiety.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis houses serving the global life sciences sector.

Basic Information

Product Name	1H-Imidazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci)
CAS No.	146091-77-2
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	5-Cyano-1-methyl-1H-imidazole-4-carbonyl chloride; 1-Methyl-5-cyanoimidazole-4-carbonyl chloride; 4-Carbonyl chloride-5-cyano-1-methylimidazole; 5-Cyano-1-methylimidazole-4-carboxylic acid chloride; 1-Methyl-5-cyano-1H-imidazole-4-carboxylic acid chloride; 1-Methyl-5-cyanoimidazole-4-carboxylic acid chloride; 146091-77-2 (CAS)
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.