Description

1H-Imidazole-5-Carbonyl Chloride, 4-Cyano-1-Methyl- (9Ci) is a highly reactive and specialized organic intermediate, crucial for constructing complex heterocyclic frameworks. Its core value lies in enabling the synthesis of advanced pharmaceutical compounds and agrochemicals through its versatile carbonyl chloride and cyano functional groups. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for novel active ingredient synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require imidazole-based active ingredients.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, polymers, and dyes with specific electronic properties.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry and organic synthesis laboratories for exploring new chemical entities.

Basic Information

Product Name	1H-Imidazole-5-Carbonyl Chloride, 4-Cyano-1-Methyl- (9Ci)
CAS No.	146091-75-0
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	4-Cyano-1-methyl-1H-imidazole-5-carbonyl chloride; 1-Methyl-4-cyanoimidazole-5-carbonyl chloride; 1-Methyl-4-cyano-1H-imidazole-5-carboxylic acid chloride; 1-Methyl-4-cyanoimidazole-5-carboxylic acid chloride; 4-Cyano-1-methylimidazole-5-carbonyl chloride; 1-Methyl-4-cyano-1H-imidazole-5-carbonyl chloride; 1-Methyl-4-cyanoimidazole-5-carboxyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Imidazole-5-Carbonyl Chloride, 4-Cyano-1-Methyl- (9Ci) adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.