Description

4-Chloro-2,3,5,6-Tetrafluorobenzoyl Chloride is a highly reactive and versatile fluorinated aromatic acid chloride intermediate. Its value lies in its ability to introduce the unique 4-chloro-2,3,5,6-tetrafluorobenzoyl moiety, which imparts enhanced stability, lipophilicity, and specific electronic properties to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for synthesizing advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorinated aromatic ring enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its ability to modify electronic properties and stability.
• Polymer Modification: Acts as a grafting or functionalization agent to introduce fluorinated aromatic groups into polymer chains, improving chemical resistance and surface properties.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic substitution reactions to create complex fluorinated aromatic ketones, amides, and esters.
• Dye & Pigment Manufacturing: Intermediate for producing specialized fluorinated dyes and pigments with improved lightfastness and color properties.

Basic Information

Product Name	4-Chloro-2,3,5,6-Tetrafluorobenzoyl Chloride
CAS No.	145572-10-7
Molecular Formula	C7Cl2F4O
Molecular Weight	246.98 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-chlorobenzoyl chloride; 4-Chlorotetrafluorobenzoyl chloride; Perfluorochlorobenzoyl chloride; Benzoyl chloride, 4-chloro-2,3,5,6-tetrafluoro-; 4-Chloro-2,3,5,6-tetrafluorobenzoic acid chloride; TFB-Cl (common abbreviation)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3,5,6-Tetrafluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Acidity (Titration)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.