Description

tert-Butyldiphenylsilyl Cyanide CAS NO 145545-43-3 is a versatile organosilicon reagent primarily used as a cyanide source and protecting group agent in advanced organic synthesis. Its value lies in its ability to introduce the cyanide functional group under mild conditions and its utility in the protection of alcohols and other sensitive moieties. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the introduction of nitrile groups in the development of active pharmaceutical ingredients (APIs).
• Alcohol Protection: Acts as a silylating agent to protect hydroxyl groups during multi-step synthetic sequences, particularly where robust protection is required.
• Nucleoside & Carbohydrate Chemistry: Employed in the modification and protection of sugar derivatives and nucleosides.
• Agrochemical Research: Used in the synthesis of herbicides, fungicides, and insecticides that contain nitrile functionalities.
• Material Science Precursor: Serves as a precursor for silicon-containing polymers and advanced materials.
• Process Chemistry & Scale-up: Suitable for kilogram-scale production in GMP and non-GMP environments for commercial manufacturing.

Basic Information

Product Name	tert-Butyldiphenylsilyl Cyanide
CAS No.	145545-43-3
Molecular Formula	C₁₇H₁₉NSi
Molecular Weight	265.43 g/mol
Synonyms	tert-Butyldiphenylsilyl Cyanide; Cyanotert-butyldiphenylsilane; TBDPS-CN; t-Butyldiphenylsilyl Cyanide; (tert-Butyldiphenylsilyl)cyanide; Cyanotriphenylsilane, tert-butyl-; Silane, cyanotert-butyldiphenyl-; 145545-43-3
EINECS	Contact for details

Quality Control

Our tert-Butyldiphenylsilyl Cyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥98% (by HPLC/NMR). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards to support its use in research and regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.