Description

4-(2-Amino-6-Chloro-9H-Purin-9-Yl)-1,3-Dioxolane-2-Methanol is a high-purity nucleoside analogue derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a versatile scaffold for the development of novel antiviral and anticancer therapeutics, where precise molecular structure is paramount. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation nucleoside-based drugs, particularly those targeting viral polymerases and cellular enzymes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex nucleoside analogues for antiviral and anticancer drug candidates.
• Antiviral Drug Research: Used in the R&D of novel therapeutics targeting viruses such as hepatitis and herpes, leveraging its modified purine base structure.
• Oncology Research: Serves as a building block for creating potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the mechanism of action of nucleoside-processing enzymes.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for commercial pharmaceutical production.
• Custom Synthesis: A starting material for the custom manufacturing of specialized nucleoside derivatives for targeted research programs.

Basic Information

Product Name	4-(2-Amino-6-Chloro-9H-Purin-9-Yl)-1,3-Dioxolane-2-Methanol
CAS No.	145514-00-7
Molecular Formula	C9H10ClN5O3
Molecular Weight	271.66 g/mol
Synonyms	2-Amino-6-chloro-9-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]purine; 6-Chloro-2-amino-9-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)purine; 2-Amino-6-chloropurine dioxolane methanol derivative; 9-(2-(Hydroxymethyl)-1,3-dioxolan-4-yl)-2-amino-6-chloropurine; 4-(2-Amino-6-chloro-9H-purin-9-yl)-1,3-dioxolane-2-methanol; 145514-00-7; 2-Amino-6-chloro-9-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)-9H-purine
EINECS	Contact for details

Quality Control

Our 4-(2-Amino-6-Chloro-9H-Purin-9-Yl)-1,3-Dioxolane-2-Methanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) are available for every batch and supplied upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.