Description

[1,1-Bibicyclo[1.1.1]Pentane]-3-Carbonylchloride(9Ci) is a highly reactive and synthetically valuable organochloride compound, serving as a crucial building block in advanced organic synthesis. Its unique, highly strained bicyclo[1.1.1]pentane (BCP) scaffold is prized for introducing three-dimensionality and improving physicochemical properties in target molecules. This compound is essential for research chemists and process development scientists working in pharmaceutical discovery, agrochemical development, and materials science.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing drug candidates featuring the bicyclo[1.1.1]pentane bioisostere, used to replace aromatic rings or tert-butyl groups to enhance metabolic stability, solubility, and membrane permeability.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the BCP core can improve activity profiles and environmental degradation characteristics.
• Materials Science Research: Monomer or cross-linking agent for creating polymers with unique mechanical or optical properties due to the rigid, strained hydrocarbon framework.
• Ligand and Catalyst Development: Starting material for constructing novel, sterically demanding phosphine or N-heterocyclic carbene (NHC) ligands used in catalysis.
• Chemical Biology Probes: Used to create molecular probes and tags with the BCP motif for studying protein-ligand interactions or cellular imaging.
• High-Value Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals for electronics and performance materials.

Basic Information

Item	Details
Product Name	[1,1-Bibicyclo[1.1.1]Pentane]-3-Carbonylchloride(9Ci)
CAS No.	145143-26-6
Molecular Formula	C7H7ClO
Molecular Weight	142.58 g/mol
Synonyms	1,1'-Bicyclo[1.1.1]pentane-3-carbonyl chloride; 3-(Chlorocarbonyl)bicyclo[1.1.1]pentane-1-carbonitrile; Bicyclo[1.1.1]pentane-1,3-dicarbonyl chloride (partial); BCP-acyl chloride; [1.1.1]Propellane-3-carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Every batch of [1,1-Bibicyclo[1.1.1]Pentane]-3-Carbonylchloride(9Ci) is produced and analyzed under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and highly volatile nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.