Description

N6-Benzoyl-2'-Fluoro-2'-Deoxyarabinoadenosine is a chemically modified nucleoside analog, specifically a fluorinated arabinose derivative of adenosine protected at the N6 position. This compound is a critical high-purity building block in oligonucleotide synthesis, particularly for the development of antisense therapeutics and diagnostic probes. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CDMOs engaged in the production of novel nucleic acid-based drugs.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite precursor for the incorporation of modified bases into DNA/RNA strands.
• Antisense Drug Development: Used in the research and manufacturing of therapeutic oligonucleotides designed to modulate gene expression.
• Diagnostic Probe Synthesis: Essential for creating fluorescently labeled or otherwise tagged probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry Research: Acts as a scaffold for studying structure-activity relationships (SAR) in nucleoside-based drug discovery.
• Bioconjugation: The benzoyl protecting group provides a handle for further chemical modifications and linker attachments.
• GMP Manufacturing: Supplied as a raw material under controlled conditions for the production of active pharmaceutical ingredients (APIs) in oligonucleotide therapies.

Basic Information

Item	Details
Product Name	N6-Benzoyl-2'-Fluoro-2'-Deoxyarabinoadenosine
CAS No.	144924-99-2
Molecular Formula	C17H17FN6O4
Molecular Weight	388.35 g/mol
Synonyms	2'-Fluoro-2'-deoxyarabinoadenosine, N6-Benzoyl-; 9-[(2R,3S,4R,5R)-5-(Benzoylamino)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurine; 2'-F-ara-A(N-Bz); 2'-Fluoro-arabinofuranosyladenine, N6-Benzoyl derivative; N6-Benzoyl-2'-F-ara-A; Bz-2'F-araA; 2'-Fluoro-2'-deoxy-β-D-arabinofuranosyladenine, N6-Benzoyl-; 144924-99-2
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-2'-Fluoro-2'-Deoxyarabinoadenosine is produced and tested to meet the exacting standards required for nucleic acid synthesis. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing identity, purity, and impurity profiles. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.