Description

2'-Fluoro-2'-Deoxy-N6,N6-Dimethylarabinoadenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its primary value lies in its role as a critical intermediate for the development of novel therapeutic agents, particularly antisense oligonucleotides and other nucleic acid-based drugs. This high-purity compound is essential for pharmaceutical R&D, biotechnology companies, and academic research institutions focused on advancing targeted genetic therapies and antiviral treatments.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A crucial phosphoramidite precursor for constructing oligonucleotides designed for gene silencing and therapeutic modulation of RNA.
• Pharmaceutical Intermediate: Serves as a key building block in the research and development of novel antiviral and anticancer nucleoside analog prodrugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to enhance the metabolic stability, binding affinity, and efficacy of nucleic acid-based drug candidates.
• Bioconjugation and Probe Development: Employed in creating labeled nucleotides for diagnostic assays, imaging probes, and targeted drug delivery systems.
• Academic & Institutional R&D: Fundamental research tool for studying enzyme mechanisms, nucleic acid biochemistry, and the development of new therapeutic modalities.

Basic Information

Product Name	2'-Fluoro-2'-Deoxy-N6,N6-Dimethylarabinoadenosine
CAS No.	144924-81-2
Molecular Formula	C12H17FN6O3
Molecular Weight	312.30 g/mol
Synonyms	2'-F-2'-d-N6,N6-Dimethyl-ara-A; 2'-Fluoro-2'-deoxy-N6,N6-dimethyl-9-β-D-arabinofuranosyladenine; 9-[(2R,3S,4S,5R)-5-(Fluoromethyl)-3,4-dihydroxytetrahydrofuran-2-yl]-N6,N6-dimethyl-9H-purin-6-amine; 2'-Fluoro-N6,N6-dimethyl-2'-deoxyarabinoadenosine; 2'-F-N6,N6-Dimethyl-ara-A; 2'-Fluoro-2'-deoxy-N6,N6-dimethyladenosine arabinoside; 2'-F-2'-d-DM-araA
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2'-Deoxy-N6,N6-Dimethylarabinoadenosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material for regulatory filing support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.