Description

Benzeneacetyl Chloride, α-Hydroxy-3-Methyl- (9Ci) is a specialized organic acid chloride derivative, identified by CAS No. 144916-98-3. This compound serves as a critical high-purity building block in advanced organic synthesis, enabling the introduction of functionalized phenylacetyl moieties. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of proprietary drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides with specific activity profiles.
• Peptide Mimetics & Conjugation: Facilitates the acylation of amino groups in peptides or other biomolecules to create novel conjugates for research.
• Material Science Research: Employed in the synthesis of specialized monomers for high-performance polymers and resins.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or other biological macromolecules in probe development.
• Academic & Industrial R&D: Serves as a versatile reagent for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	Benzeneacetyl Chloride, α-Hydroxy-3-Methyl- (9Ci)
CAS No.	144916-98-3
Molecular Formula	C9H9ClO2
Molecular Weight	184.62 g/mol
Synonyms	2-Hydroxy-2-(3-methylphenyl)acetyl Chloride; α-Hydroxy-3-methylbenzeneacetyl Chloride; (3-Methylmandeloyl) Chloride; 2-Hydroxy-2-(m-tolyl)acetyl Chloride; 3-Methylmandelic Acid Chloride; m-Tolylglycolic Acid Chloride; (RS)-2-Hydroxy-2-(3-methylphenyl)acetyl Chloride; 2-(3-Methylphenyl)-2-oxoethyl Chloroformate (tautomeric form)
EINECS	Contact for details

Quality Control

Every batch of Benzeneacetyl Chloride, α-Hydroxy-3-Methyl- (9Ci) is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through comprehensive analytical protocols including NMR, HPLC, and titration methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and strong acid/organic solvent nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, heat, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.