Description

Benzeneacetyl Chloride, 3,5-Difluoro-α-Hydroxy- (9Ci) is a specialized fluorinated aromatic building block, a key intermediate in modern synthetic chemistry. Its value lies in the precise introduction of fluorine atoms and reactive functional groups, enabling the synthesis of complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material science sectors, where it serves as a critical precursor for active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine substitution enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, improving charge transport and thermal stability.
• Peptide Mimetics & Protease Inhibitors: The α-hydroxy acid chloride moiety is valuable for constructing peptide analogs and enzyme inhibitors in medicinal chemistry.
• Fluorinated Polymer Monomer: Can be utilized to synthesize specialty polymers with unique surface properties, chemical resistance, and optical characteristics.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organofluorine chemistry and novel synthetic methodologies.

Basic Information

Item	Details
Product Name	Benzeneacetyl Chloride, 3,5-Difluoro-α-Hydroxy- (9Ci)
CAS No.	144916-95-0
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	3,5-Difluoro-2-hydroxy-2-phenylacetyl chloride; 2-(3,5-Difluorophenyl)-2-hydroxyacetyl chloride; α-Hydroxy-3,5-difluorobenzeneacetyl chloride; (3,5-Difluorophenyl)(hydroxy)acetyl chloride; 3,5-Difluoromandeloyl chloride; 2-Hydroxy-2-(3,5-difluorophenyl)acetyl chloride
EINECS	Contact for details

Quality Control

Our production of Benzeneacetyl Chloride, 3,5-Difluoro-α-Hydroxy- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 aligned practices for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.