Description

Benzeneacetyl Chloride, 3,4-Difluoro-α-Hydroxy- (9Ci) is a specialized fluorinated organic intermediate that combines an acid chloride functional group with a hydroxyl moiety on a difluorinated aromatic ring. This unique bifunctional structure makes it a valuable building block for synthesizing complex molecules with tailored properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic cores in electronic display and lighting components.
• Polymer Modification: Employed to introduce reactive sites and fluorinated aromatic units into specialty polymers for enhanced performance.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and creating novel fluorinated compounds in academic and industrial R&D labs.
• Peptide & Protein Conjugation: The acid chloride group can be used for selective acylation reactions in bioconjugation chemistry.

Basic Information

Product Name	Benzeneacetyl Chloride, 3,4-Difluoro-α-Hydroxy- (9Ci)
CAS No.	144916-94-9
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-(3,4-Difluorophenyl)-2-hydroxyacetyl chloride; 3,4-Difluoromandeloyl chloride; α-Hydroxy-3,4-difluorobenzeneacetyl chloride; (3,4-Difluorophenyl)(hydroxy)acetyl chloride; 2-Hydroxy-2-(3,4-difluorophenyl)acetyl chloride; 3,4-Difluoro-α-hydroxybenzeneacetyl chloride
EINECS	Contact for details

Quality Control

Our Benzeneacetyl Chloride, 3,4-Difluoro-α-Hydroxy- (9Ci) is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system is designed to meet the rigorous demands of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.