Description

1-[5-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl]-2,4(1H,3H)-Pyrimidinedione is a sophisticated nucleoside analog intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a key building block for the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases. This high-purity compound is essential for pharmaceutical companies, contract research organizations (CROs), and academic research institutions engaged in the discovery and process development of next-generation fluorinated nucleoside drugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of fluorinated nucleoside analogs with potential antiviral and anticancer activity.
• Antiviral Drug Research: Used in R&D for developing therapeutics against viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and other viral pathogens.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that target DNA/RNA synthesis in cancer cells.
• Process Chemistry & Scale-Up: Employed in process optimization and kilogram-scale synthesis for clinical trial material (CTM) and commercial Active Pharmaceutical Ingredient (API) manufacturing.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and drug resistance.
• Reference Standard: Sourced for use as a high-purity analytical reference standard in quality control (QC) and regulatory submissions.

Basic Information

Item	Detail
Product Name	1-[5-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl]-2,4(1H,3H)-Pyrimidinedione
CAS No.	144822-63-9
Molecular Formula	C36H33FN2O7
Molecular Weight	624.66 g/mol
Synonyms	2'-Deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)-β-D-arabinouridine; 5'-O-DMT-2'-F-ara-U; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-β-D-arabinofuranosyl]uracil; 2'-Fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-β-D-arabinouridine; DMT-2'F-araU; 2'-F-araU-DMT; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-β-D-arabinouridine
EINECS	Contact for details

Quality Control

Our 1-[5-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl]-2,4(1H,3H)-Pyrimidinedione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.