Description

5'-o-Acetyl-3'-Azido-N2-Palmitoyl-2',3'-Dideoxyguanosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical research and development. This compound is specifically engineered for its role as a critical intermediate in the synthesis of novel antiviral and anticancer prodrugs, particularly within the nucleoside reverse transcriptase inhibitor (NRTI) class. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing next-generation therapeutics targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of nucleoside-based antiviral drugs, including potential treatments for HIV and hepatitis.
• Antiviral Prodrug Development: Used in research to create prodrug forms of dideoxyguanosine analogs, aiming to improve bioavailability and targeted delivery.
• Oncology Research: Serves as a building block for developing nucleotide analogs that may interfere with cancer cell DNA replication.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of modified nucleosides and their mechanisms of action.
• Medicinal Chemistry: A valuable scaffold for the design and synthesis of new chemical entities (NCEs) with potential therapeutic activity.
• Process Development: Used in scaling up and optimizing synthetic routes for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-o-Acetyl-3'-Azido-N2-Palmitoyl-2',3'-Dideoxyguanosine
CAS No.	144742-33-6
Molecular Formula	C30H46N8O6
Molecular Weight	590.74 g/mol
Synonyms	2',3'-Dideoxy-N2-palmitoylguanosine 5'-acetate 3'-azide; 3'-Azido-2',3'-dideoxy-N2-palmitoylguanosine 5'-acetate; 5'-O-Acetyl-3'-azido-2',3'-dideoxy-N2-palmitoylguanosine; Palmitoyl-3'-azido-2',3'-ddG 5'-acetate; AZT-Guanosine Palmitoyl Acetyl Derivative; N2-Palmitoyl-3'-azido-2',3'-dideoxyguanosine 5'-acetate; 3'-Azido-ddG(Palmitoyl) 5'-Acetate
EINECS	Contact for details

Quality Control

Our 5'-o-Acetyl-3'-Azido-N2-Palmitoyl-2',3'-Dideoxyguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.