Description

2-(Pyridin-2-Yl)Acetyl Chloride is a versatile and reactive organic intermediate, primarily valued for its role as a key building block in the synthesis of complex molecules. Its structure, featuring both a pyridine ring and an acid chloride functional group, makes it an essential reagent for introducing the 2-pyridylacetyl moiety into target compounds. This product is critical for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, where the pyridyl moiety can enhance biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the development of novel organic materials, including liquid crystals and functional polymers.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis and scale-up projects.

Basic Information

Product Name	2-(Pyridin-2-Yl)Acetyl Chloride
CAS No.	144659-13-2
Molecular Formula	C7H6ClNO
Molecular Weight	155.58 g/mol
Synonyms	2-Pyridylacetyl Chloride; 2-(2-Pyridinyl)acetyl Chloride; (Pyridin-2-yl)acetyl Chloride; 2-Pyridineacetyl Chloride; α-Chloro-2-pyridyl Methyl Ketone; 2-Pyridylacetic Acid Chloride; 2-(Pyridin-2-yl)acetyl Chloride Hydrochloride (salt form); 2-Pyridylacetyl Chloride Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Pyridin-2-Yl)Acetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and reactive acid chloride nature, this material must be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.