Description

3',5'-Di-o-Acetyl O6-Benzyl-2'-Deoxyguanosine CAS NO 144640-75-5 is a key protected nucleoside derivative, specifically a modified deoxyguanosine, widely used as a critical building block in oligonucleotide synthesis. Its primary value lies in enabling the precise construction of DNA and RNA sequences for research and therapeutic development by protecting reactive sites during chemical coupling steps. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense oligonucleotides, aptamers, and other nucleic acid-based technologies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a protected phosphoramidite precursor for the automated synthesis of DNA strands.
• Antisense Oligonucleotide (ASO) Development: A crucial raw material in the manufacture of therapeutic oligonucleotides targeting genetic diseases.
• Research & Diagnostic Probe Synthesis: Used to create labeled or modified DNA probes for PCR, sequencing, and hybridization assays.
• Aptamer Production: Enables the chemical synthesis of specific DNA or RNA aptamers for therapeutic and diagnostic applications.
• siRNA and miRNA Synthesis: Acts as a building block in the synthesis of short interfering RNA (siRNA) and microRNA (miRNA) molecules for gene silencing studies.
• Pharmaceutical Intermediate: Employed in the research and development stages of novel nucleic acid-based drugs.

Basic Information

Product Name	3',5'-Di-o-Acetyl O6-Benzyl-2'-Deoxyguanosine
CAS No.	144640-75-5
Molecular Formula	C₂₁H₂₃N₅O₆
Molecular Weight	441.44 g/mol
Synonyms	O6-Benzyl-2'-deoxyguanosine 3',5'-diacetate; 2'-Deoxy-O6-benzylguanosine 3',5'-diacetate; 3',5'-Di-O-acetyl-O6-benzyl-2'-deoxyguanosine; 3',5'-Di-O-acetyl-O6-benzylguanosine; 3',5'-Diacetyl-O6-benzyl-2'-deoxyguanosine; O6-Bn-dG 3',5'-diacetate; Protected 2'-Deoxyguanosine Derivative
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl O6-Benzyl-2'-Deoxyguanosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can provide material traceable to GMP-grade standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.